Gene
magi2b
- ID
- ZDB-GENE-141211-6
- Name
- membrane associated guanylate kinase, WW and PDZ domain containing 2b
- Symbol
- magi2b Nomenclature History
- Previous Names
-
- si:ch211-127m7.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable SMAD binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Predicted to be involved in receptor clustering and signal transduction. Predicted to act upstream of or within phosphorylation. Predicted to be located in several cellular components, including bicellular tight junction; centriole; and photoreceptor inner segment. Predicted to be active in cell-cell junction; cytoplasm; and dendrite. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Jobst-Schwan et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 15 | Alliance | Nephrotic syndrome, type 15 | 617609 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR001202 | WW domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR041489 | PDZ domain 6 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | PDZ domain | PDZ domain 6 | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q467 | InterPro | 1146 | |||||||||
| UniProtKB:A0A8M9PEF7 | InterPro | 1145 | |||||||||
| UniProtKB:A0A8M9PR83 | InterPro | 697 | |||||||||
| UniProtKB:A0A8M9PYZ7 | InterPro | 1171 | |||||||||
| UniProtKB:A0A8M9Q8C7 | InterPro | 1152 | |||||||||
| UniProtKB:A0AB32TH84 | InterPro | 1170 | |||||||||
| UniProtKB:A0AB32TH86 | InterPro | 1178 | |||||||||
| UniProtKB:A0AB32TIM4 | InterPro | 1154 | |||||||||
| UniProtKB:A0AB32TIR6 | InterPro | 1158 | |||||||||
| UniProtKB:A0AB32TJI5 | InterPro | 1314 | |||||||||
| UniProtKB:A0AB32TJZ2 | InterPro | 1153 | |||||||||
| UniProtKB:A0AB32TK92 | InterPro | 1166 | |||||||||
| UniProtKB:A0AB32TKF1 | InterPro | 1118 | |||||||||
| UniProtKB:A0AB32TMV2 | InterPro | 1160 | |||||||||
| UniProtKB:A0AB32TPK3 | InterPro | 1133 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
magi2b-201
(1)
|
Ensembl | 4,794 nt | ||
| mRNA |
magi2b-202
(1)
|
Ensembl | 3,449 nt | ||
| mRNA |
magi2b-203
(1)
|
Ensembl | 9,099 nt |
Interactions and Pathways
No data available
Plasmids
No data available