ZFIN Gene: magi2b

ZFIN ID: ZDB-GENE-141211-6

ZFIN ID: ZDB-GENE-141211-6

Gene Name:

membrane associated guanylate kinase, WW and PDZ domain containing 2b

Gene Symbol:

magi2b Nomenclature History

Previous Name:

si:ch211-127m7.3 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 25 Mapping Details/Browsers

Description:

Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2).

Genome Resources:

Alliance (1), Gene:100001810 (1), Ensembl(GRCz11):ENSDARG00000073769 (1)

GENE EXPRESSION
All Expression Data:	Fig. S3 from Jobst-Schwan et al., 2019

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
cl608	Small Deletion	Unknown	Unknown
cl609	Small Deletion	Unknown	Unknown
sa44295	Point Mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-magi2b	cl608 cl609	1

PHENOTYPE No data available

DISEASE ASSOCIATED WITH magi2b HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nephrotic syndrome type 15	Alliance	Nephrotic syndrome, type 15	617609

DISEASE ASSOCIATED WITH magi2b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	receptor clustering (more)
Cellular Component	cell-cell junction (more)
Molecular Function	beta-1 adrenergic receptor binding (more)

GO Terms (all 9)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	magi2b-202 (1)	3449	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM magi2b No data available

MARKER RELATIONSHIPS

magi2b Contained in:

[BAC] CH211-127M7 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_021470685 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:AL953857 (1)	175586 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7FH65 (1)	1332 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 17)

ORTHOLOGY for magi2b ( Chr: 25 )

CITATIONS (13)

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