ZFIN is now using GRCz12tu for Genomic Data
Gene
smad4b
- ID
- ZDB-GENE-060130-140
- Name
- SMAD family member 4b
- Symbol
- smad4b Nomenclature History
- Previous Names
-
- gb:cr929477
- sb:eu670
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in animal gross anatomical part developmental process and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; disease of cellular proliferation (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; and juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome. Orthologous to human SMAD4 (SMAD family member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu670 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| juvenile polyposis syndrome | Alliance | Polyposis, juvenile intestinal | 174900 |
| juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome | Alliance | Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome | 175050 |
| pancreatic carcinoma | Alliance | Pancreatic cancer, somatic | 260350 |
| Myhre syndrome | 139210 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M3B256 | InterPro | 505 |
| UniProtKB:A0A8M9PY51 | InterPro | 341 |
| UniProtKB:A0AC58JNF2 | InterPro | 505 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
smad4 (1 of many)-201
(1)
|
Ensembl | 1,104 nt | ||
| mRNA |
smad4b-201
(1)
|
Ensembl | 669 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers