ZFIN ID: ZDB-GENE-141211-38
Gene Name: v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog b (paralog b)
Gene Symbol: mafb    Nomenclature History

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Previous Name: si:ch73-337g9.1

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Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Is expressed in blood; brain; kidney; and spleen. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Orthologous to human MAF (MAF bZIP transcription factor).
Genome Resources: Alliance (1),  Gene:100537332 (1),  Ensembl(GRCz11):ENSDARG00000076520 (2)
Note: This gene, the ortholog and one of the zebrafish genome duplicates of the human MAF gene, has the same gene symbol as a different human gene (MAFB). This zebrafish mafb gene is not the ortholog of human MAFB. The identical gene symbol for non-orthologous genes is due to the genome duplicate naming conventions of the zebrafish nomenclature guidelines. The zebrafish orthologs of the human MAFB gene are mafba (ZDB-GENE-980526-515) and mafbb (ZDB-GENE-010605-4).
GENE EXPRESSION
All Expression Data: 6 figures from 2 publications
Directly Submitted Expression Data: 4 figures (15 images) from Rauch et al., 2003 [c-maf]
Wild-type Stages, Structures: Pharyngula:Prim-25 (36.0h-42.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24734 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mafb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Ayme-Gripp syndrome Alliance Ayme-Gripp syndrome 601088
    cataract 21 multiple types Alliance Cataract 21, multiple types 610202
    DISEASE ASSOCIATED WITH mafb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component host cell nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mafb-201 (1)    Ensembl 2217
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mafb No data available
    MARKER RELATIONSHIPS
    mafb Contained in: [BAC] CH73-337G9 (1)
    mafb Encodes: [EST] c-maf (2) (order this), fl13d12 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001316669 (1)
    Genomic GenBank:FP243274 (1) 106809 nt
    Select Tool
    Polypeptide UniProtKB:F1Q513 (1) 327 aa
    Sequence Information (all 13)
    ORTHOLOGY for mafb ( Chr: 25 )
    CITATIONS (19)