Gene
kcnt1b
- ID
- ZDB-GENE-141210-6
- Name
- potassium sodium-activated channel subfamily T member 1b
- Symbol
- kcnt1b Nomenclature History
- Previous Names
-
- si:dkey-21e5.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable intracellular sodium-activated potassium channel activity and outward rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in Kupffer's vesicle; brain; neural tube; otic vesicle; and peripheral olfactory organ. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5 and developmental and epileptic encephalopathy 14. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Silic et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nocturnal frontal lobe epilepsy 5 | Alliance | Epilepsy nocturnal frontal lobe, 5 | 615005 |
| developmental and epileptic encephalopathy 14 | Alliance | Developmental and epileptic encephalopathy 14 | 614959 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M9PZ66 | InterPro | 1261 |
| UniProtKB:A0A8M9QEY3 | InterPro | 1254 |
| UniProtKB:A0A8M9Q4Y2 | InterPro | 1260 |
| UniProtKB:A0A8M9PZ72 | InterPro | 1240 |
| UniProtKB:A0A8M9Q9W1 | InterPro | 1247 |
| UniProtKB:A0A8M9PLK9 | InterPro | 1219 |
| UniProtKB:A0AB32TRW8 | InterPro | 1103 |
| UniProtKB:A0AB32TS07 | InterPro | 1101 |
| UniProtKB:A0AB32TSV6 | InterPro | 1095 |
| UniProtKB:A0AB32TUI0 | InterPro | 1221 |
| UniProtKB:A0AB32TWF5 | InterPro | 1102 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnt1-202
(1)
|
Ensembl | 3,321 nt | ||
| mRNA |
kcnt1-204
(1)
|
Ensembl | 3,363 nt | ||
| mRNA |
kcnt1b-201
(1)
|
Ensembl | 3,385 nt | ||
| mRNA |
kcnt1b-203
(1)
|
Ensembl | 2,037 nt |
Interactions and Pathways
No data available
Plasmids
- Comparative Orthology
- Alliance