ZFIN ID: ZDB-GENE-140106-84
Gene Name: engulfment and cell motility 2
Gene Symbol: elmo2    Nomenclature History

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Previous Name: zmp:0000001124 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to be involved in cell migration; cell-cell adhesion; and cytoskeleton organization. Is expressed in brain; mid cerebral vein; and retinal ganglion cell layer. Orthologous to human ELMO2 (engulfment and cell motility 2).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000063527 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
imb2 Small Deletion Exon 12 Frameshift, Premature Stop CRISPR
imb3 Small Deletion Exon 12 Frameshift, Premature Stop CRISPR
imb4 Small Deletion Exon 12 Unknown CRISPR
sa17632 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34996 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41743 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-elmo2 1
    CRISPR2-elmo2
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH elmo2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Vascular malformation, primary intraosseous 606893
    DISEASE ASSOCIATED WITH elmo2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell-cell adhesion (more)
    Molecular Function Rac GTPase binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA elmo2-201 (1)    Ensembl 2140
    elmo2-203 (1)    Ensembl 720
    elmo2-204 (1)    Ensembl 98
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM elmo2 No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Polypeptide UniProtKB:A0A0G2KRJ3 (1) 675 aa
    Sequence Information (all 4)
    ORTHOLOGY for elmo2 ( Chr: 11 )
    CITATIONS (15)