ZFIN is now using GRCz12tu for Genomic Data
Gene
man2b2
- ID
- ZDB-GENE-140106-166
- Name
- mannosidase, alpha, class 2B, member 2
- Symbol
- man2b2 Nomenclature History
- Previous Names
-
- zmp:0000001206 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type I. Orthologous to human MAN2B2 (mannosidase alpha class 2B member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Congenital disorder of glycosylation type 1EE with or without immunodeficiency | 621140 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000602 | Glycoside hydrolase family 38, N-terminal domain |
| Domain | IPR011682 | Glycosyl hydrolase family 38, C-terminal |
| Domain | IPR015341 | Glycoside hydrolase family 38, central domain |
| Domain | IPR041147 | Glycosyl hydrolases family 38, C-terminal domain |
| Family | IPR050843 | Glycosyl Hydrolase Family 38 |
| Homologous_superfamily | IPR011013 | Galactose mutarotase-like domain superfamily |
| Homologous_superfamily | IPR011330 | Glycoside hydrolase/deacetylase, beta/alpha-barrel |
| Homologous_superfamily | IPR013780 | Glycosyl hydrolase, all-beta |
| Homologous_superfamily | IPR027291 | Glycoside hydrolase 38, N-terminal domain superfamily |
| Homologous_superfamily | IPR028995 | Glycoside hydrolase families 57/38, central domain superfamily |
| Homologous_superfamily | IPR037094 | Glycoside hydrolase family 38, central domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Galactose mutarotase-like domain superfamily | Glycoside hydrolase 38, N-terminal domain superfamily | Glycoside hydrolase/deacetylase, beta/alpha-barrel | Glycoside hydrolase families 57/38, central domain superfamily | Glycoside hydrolase family 38, central domain | Glycoside hydrolase family 38, central domain superfamily | Glycoside hydrolase family 38, N-terminal domain | Glycosyl hydrolase, all-beta | Glycosyl Hydrolase Family 38 | Glycosyl hydrolase family 38, C-terminal | Glycosyl hydrolases family 38, C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z1P3 | InterPro | 979 | |||||||||||
| UniProtKB:A0A8M1PZ41 | InterPro | 1006 | |||||||||||
| UniProtKB:A0AC58G3Q3 | InterPro | 735 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
man2b2-201
(1)
|
Ensembl | 3,231 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance