Gene

plxna1a

ID
ZDB-GENE-140106-137
Name
plexin A1a
Symbol
plxna1a Nomenclature History
Previous Names
  • zmp:0000001177 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable semaphorin receptor activity. Acts upstream of or within optic cup morphogenesis involved in camera-type eye development. Predicted to be located in membrane. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Is expressed in nervous system; neural rod; optic vesicle; otic vesicle; and presumptive neural retina. Orthologous to human PLXNA1 (plexin A1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Cechmanek et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With plxna1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Dworschak-Punetha neurodevelopmental syndrome 619955
Associated With plxna1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001627 Sema domain
Domain IPR002909 IPT domain
Domain IPR013548 Plexin, cytoplasmic RasGAP domain
Domain IPR016201 PSI domain
Domain IPR041019 Plexin, TIG domain 1
Domain IPR041362 Plexin, TIG domain 2
Family IPR031148 Plexin family
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036352 Sema domain superfamily
Repeat IPR002165 Plexin repeat
Domain Details Per Protein
Protein Length Immunoglobulin E-set Immunoglobulin-like fold IPT domain Plexin, cytoplasmic RasGAP domain Plexin family Plexin repeat Plexin, TIG domain 1 Plexin, TIG domain 2 PSI domain Rho GTPase activation protein Sema domain Sema domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A140LGG1 1891
UniProtKB:B6E520 220
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations