Gene
plxna1a
- ID
- ZDB-GENE-140106-137
- Name
- plexin A1a
- Symbol
- plxna1a Nomenclature History
- Previous Names
-
- zmp:0000001177 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have semaphorin receptor activity. Predicted to be involved in several processes, including regulation of GTPase activity; regulation of cell morphogenesis; and semaphorin-plexin signaling pathway involved in axon guidance. Predicted to localize to integral component of plasma membrane and semaphorin receptor complex. Is expressed in nervous system; optic vesicle; otic vesicle; and presumptive neural retina. Orthologous to human PLXNA1 (plexin A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Dworschak-Punetha neurodevelopmental syndrome | 619955 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001627 | Sema domain |
| Domain | IPR002909 | IPT domain |
| Domain | IPR013548 | Plexin, cytoplasmic RasGAP domain |
| Domain | IPR016201 | PSI domain |
| Domain | IPR041019 | Plexin, TIG domain 1 |
| Domain | IPR041362 | Plexin, TIG domain 2 |
| Domain | IPR046800 | Plexin, cytoplasmic RhoGTPase-binding domain |
| Family | IPR031148 | Plexin family |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036352 | Sema domain superfamily |
| Repeat | IPR002165 | Plexin repeat |
Domain Details Per Protein
| Protein | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Plexin, cytoplasmic RasGAP domain | Plexin, cytoplasmic RhoGTPase-binding domain | Plexin family | Plexin repeat | Plexin, TIG domain 1 | Plexin, TIG domain 2 | PSI domain | Rho GTPase activation protein | Sema domain | Sema domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z3W4
|
1891 | ||||||||||||||
|
UniProtKB:A0A8M1RJK2
|
1889 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
plxna1a-201
(1)
|
Havana | 9538 nt |
Interactions and Pathways
No data available
Plasmids
No data available