Gene

prkcab

ID

ZDB-GENE-131121-412

Name

protein kinase C, alpha, b

Symbol

prkcab Nomenclature History

Previous Names

si:ch1073-370j18.1
si:ch73-374l24.1

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have anion binding activity; calcium-dependent protein kinase C activity; and metal ion binding activity. Predicted to be involved in several processes, including calcium ion-regulated exocytosis of neurotransmitter; positive regulation of transport; and protein phosphorylation. Is expressed in brain and retinal inner nuclear layer.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Haug et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkcab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Pituitary tumor, invasive

Associated With prkcab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000008	C2 domain
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain	IPR017892	Protein kinase, C-terminal
Domain	IPR020454	Diacylglycerol/phorbol-ester binding
Family	IPR014375	Protein kinase C, alpha/beta/gamma types
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR046349	C1-like domain superfamily

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	C1-like domain superfamily	C2 domain	C2 domain superfamily	Diacylglycerol/phorbol-ester binding	Protein kinase, ATP binding site	Protein kinase C, alpha/beta/gamma types	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Protein kinase, C-terminal	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M3AR84 InterPro	681
UniProtKB:A0A8M3B1B9 InterPro	671

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	prkca-203 (1) Ensembl	Havana	2288 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	si:ch1073-370j18.1-001 (1) Ensembl	Havana	350 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations