Gene

pdgfbb

ID

ZDB-GENE-131121-332

Name

platelet-derived growth factor beta polypeptide b

Symbol

pdgfbb Nomenclature History

Previous Names

sb:eu2436
si:dkey-110g7.5

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have platelet-derived growth factor receptor binding activity. Predicted to be involved in several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; and positive regulation of protein phosphorylation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Is expressed in several structures, including basal plate midbrain region; brain; forebrain neural keel; forebrain neural rod; and notochord. Orthologous to human PDGFB (platelet derived growth factor subunit B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu2436 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pdgfbb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
basal ganglia calcification	Alliance	Basal ganglia calcification, idiopathic, 5	615483
dermatofibrosarcoma protuberans	Alliance	Dermatofibrosarcoma protuberans	607907
		Meningioma, SIS-related	607174

Associated With pdgfbb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023581	Platelet-derived growth factor, conserved site
Domain	IPR000072	PDGF/VEGF domain
Homologous_superfamily	IPR029034	Cystine-knot cytokine

Domain Details Per Protein

Protein	Length	Cystine-knot cytokine	PDGF/VEGF domain	Platelet-derived growth factor, conserved site
UniProtKB:A0A8M9PEQ6 InterPro	483
UniProtKB:A0A2R8Q0D8 InterPro	483
UniProtKB:A0A8M9PWR6 InterPro	482
UniProtKB:A0A8M9PRI9 InterPro	482

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pdgfbb-201 (1) Ensembl	Havana	3821 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations