Gene

pdgfbb

ID
ZDB-GENE-131121-332
Name
platelet-derived growth factor beta polypeptide b
Symbol
pdgfbb Nomenclature History
Previous Names
  • sb:eu2436
  • si:dkey-110g7.5
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable platelet-derived growth factor receptor binding activity. Involved in several processes, including epicardial cell to mesenchymal cell transition; negative regulation of adherens junction organization; and positive regulation of phosphatidylinositol 3-kinase signaling. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including basal plate midbrain region; brain; forebrain neural keel; forebrain neural rod; and notochord. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pdgfbb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
basal ganglia calcification Alliance Basal ganglia calcification, idiopathic, 5 615483
dermatofibrosarcoma protuberans Alliance Dermatofibrosarcoma protuberans 607907
Meningioma, SIS-related 607174
Associated With pdgfbb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023581 Platelet-derived growth factor, conserved site
Domain IPR000072 PDGF/VEGF domain
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine PDGF/VEGF domain Platelet-derived growth factor, conserved site
UniProtKB:A0A2R8Q0D8 483
UniProtKB:E7FBB3 482
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations