Gene

acvr1bb

ID
ZDB-GENE-131120-9
Name
activin A receptor type 1Bb
Symbol
acvr1bb Nomenclature History
Previous Names
  • sb:eu632
  • si:zfos-824d4.1 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have activin binding activity and activin receptor activity, type I. Predicted to be involved in several processes, including activin receptor signaling pathway; cellular response to growth factor stimulus; and protein phosphorylation. Predicted to localize to activin receptor complex. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ACVR1B (activin A receptor type 1B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2005
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acvr1bb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
pancreatic carcinoma Alliance Pancreatic cancer, somatic 260350
Associated With acvr1bb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000472 Activin types I and II receptor domain
Domain IPR000719 Protein kinase domain
Domain IPR003605 GS domain
Family IPR000333 Ser/Thr protein kinase, TGFB receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR045860 Snake toxin-like superfamily
Domain Details Per Protein
Protein Length Activin types I and II receptor domain GS domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Ser/Thr protein kinase, TGFB receptor Snake toxin-like superfamily
UniProtKB:F1QZF0 498
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations