Gene

wnk4b

ID
ZDB-GENE-131120-119
Name
WNK lysine deficient protein kinase 4b
Symbol
wnk4b Nomenclature History
Previous Names
  • wnk4l (1)
  • si:dkeyp-61g11.1
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have chloride channel inhibitor activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of potassium ion import across plasma membrane; regulation of sodium ion transport; and renal sodium ion absorption. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wnk4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Pseudohypoaldosteronism, type IIB 614491
Associated With wnk4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000719 Protein kinase domain
Domain IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine/threonine-protein kinase OSR1/WNK, CCT domain
UniProtKB:X1WGD9 1494
UniProtKB:E7FH51 1322
UniProtKB:A0A2R8QPF3 1550
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations