Gene
e2f1
- ID
- ZDB-GENE-131024-3
- Name
- E2F transcription factor 1
- Symbol
- e2f1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process; anatomical structure maturation; and cell maturation. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhang et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003316 | E2F/DP family, winged-helix DNA-binding domain |
| Domain | IPR032198 | E2F transcription factor, CC-MB domain |
| Family | IPR015633 | E2F Family |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR037241 | E2F-DP heterodimerization region |
Domain Details Per Protein
| Protein | Length | E2F/DP family, winged-helix DNA-binding domain | E2F-DP heterodimerization region | E2F Family | E2F transcription factor, CC-MB domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:H9GY24
|
|||||||
|
UniProtKB:A0A8M2BLX5
|
431 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available