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General Information
ZIRC
ZFIN ID: ZDB-GENE-130911-1
Gene Name: cytochrome P450, family 11, subfamily A, polypeptide 2
Gene Symbol: cyp11a2    Nomenclature History

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Previous Name: si:dkeyp-91c1.6

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have cholesterol monooxygenase (side-chain-cleaving) activity; heme binding activity; and iron ion binding activity. Involved in cortisol biosynthetic process. Predicted to localize to the mitochondrial inner membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Is expressed in brain and endocrine system. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1).
Genome Resources: Alliance (1),  Gene:563363 (1),  Ensembl(GRCz11):ENSDARG00000092696 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb317 Insertion Exon 1 Unknown CRISPR
ihb318 Small Deletion Exon 1 Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-cyp11a2 1
MO1-cyp11a2 N/A 1
MO2-cyp11a2 N/A 1
DISEASE ASSOCIATED WITH cyp11a2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital adrenal insufficiency Alliance Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete 613743
DISEASE ASSOCIATED WITH cyp11a2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cortisol biosynthetic process (more)
Cellular Component membrane (more)
Molecular Function cholesterol monooxygenase (side-chain-cleaving) activity (more)
GO Terms (all 20)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cyp11a2-201 (1)    Ensembl 1794
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cyp11a2 No data available
MARKER RELATIONSHIPS
cyp11a2 Contained in: [BAC] DKEYP-91C1
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:XM_021473870 (1)
Genomic GenBank:AL929050 (1) 196743 bp
Select Tool
Polypeptide UniProtKB:A0A2R8Q770 (1) 524 aa
Sequence Clusters UniGene:120805 (1)
Sequence Information (all 13)
ORTHOLOGY for cyp11a2 ( Chr: 25 )
CITATIONS (21)