ZFIN ID: ZDB-GENE-130730-1
Gene Name: v-akt murine thymoma viral oncogene homolog 1
Gene Symbol: akt1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and protein serine/threonine kinase activity. Involved in negative regulation of neuron differentiation. Is expressed in central nervous system; hindbrain neural rod; pharyngeal arch; solid lens vesicle; and somite. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; Proteus syndrome; breast cancer (multiple); pancreatic cancer (multiple); and prostate cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1).
Genome Resources: Alliance (1),  Gene:101910198 (1),  Ensembl(GRCz11):ENSDARG00000099657 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-akt1 N/A 1
MO2-akt1 N/A 1
DISEASE ASSOCIATED WITH akt1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
breast cancer Alliance Breast cancer, somatic 114480
colorectal cancer Alliance Colorectal cancer, somatic 114500
ovarian cancer Alliance Ovarian cancer, somatic 167000
Proteus syndrome Alliance Proteus syndrome, somatic 176920
Cowden syndrome 6 615109
DISEASE ASSOCIATED WITH akt1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of neuron differentiation (more)
Molecular Function ATP binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM akt1 No data available
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001281801 (1) 1425 nt
Genomic GenBank:CABZ01060334 (1) 10475 nt
Polypeptide UniProtKB:M4MD44 (1) 474 aa
Sequence Information (all 11)
ORTHOLOGY for akt1 ( Chr: 17 )
CITATIONS (21)