ZFIN ID: ZDB-GENE-130530-981
Gene Name: citron rho-interacting serine/threonine kinase a
Gene Symbol: cita    Nomenclature History

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Previous Names: cit, zmp:0000000978 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17. Orthologous to human CIT (citron rho-interacting serine/threonine kinase).
Genome Resources: Alliance (1),  Gene:100329792 (1),  Ensembl(GRCz11):ENSDARG00000089856 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10643 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12291 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12822 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26385 Point Mutation Unknown Splice Site ENU
    sa26386 Point Mutation Unknown Premature Stop ENU
    sa26387 Point Mutation Unknown Splice Site ENU
    sa33521 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38447 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cita HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary autosomal recessive microcephaly 17 Alliance Microcephaly 17, primary, autosomal recessive 617090
    DISEASE ASSOCIATED WITH cita VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular signal transduction (more)
    Cellular Component actin cytoskeleton (more)
    Molecular Function ATP binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Domain IPR000961 AGC-kinase, C-terminal
    Domain IPR001180 Citron homology (CNH) domain
    Domain IPR001849 Pleckstrin homology domain
    Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Family IPR017405 Citron Rho-interacting kinase
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Homologous_superfamily IPR011993 PH-like domain superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cita No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021476723 (1)
    Genomic GenBank:CABZ01053336 (1) 56867 nt
    Select Tool
    Polypeptide UniProtKB:E7FGD8 (1) 1989 aa
    Sequence Information (all 25)
    ORTHOLOGY for cita ( Chr: 5 )
    CITATIONS (16)