Gene
cita
- ID
- ZDB-GENE-130530-981
- Name
- citron rho-interacting serine/threonine kinase a
- Symbol
- cita Nomenclature History
- Previous Names
-
- cit
- zmp:0000000978 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17 and primary microcephaly. Orthologous to human CIT (citron rho-interacting serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 17 | Alliance | Microcephaly 17, primary, autosomal recessive | 617090 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001180 | Citron homology (CNH) domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Family | IPR050839 | Rho-associated Serine/Threonine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | C1-like domain superfamily | Citron homology (CNH) domain | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase domain | Protein kinase-like domain superfamily | Rho-associated Serine/Threonine Kinase | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FGD8 | InterPro | 1989 | ||||||||||||
| UniProtKB:A0A8M9QF24 | InterPro | 2344 | ||||||||||||
| UniProtKB:A0A8M9PZB2 | InterPro | 2358 | ||||||||||||
| UniProtKB:A0A8M9Q5W0 | InterPro | 2350 | ||||||||||||
| UniProtKB:A0A8M9QA07 | InterPro | 2336 | ||||||||||||
| UniProtKB:A0AB32TPP6 | InterPro | 1908 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance