ZFIN ID: ZDB-GENE-130530-794
Gene Name: neuronal guanine nucleotide exchange factor
Gene Symbol: ngef    Nomenclature History

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Previous Names: si:ch211-281l24.2, zmp:0000000791 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have Rho guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity. Orthologous to human NGEF (neuronal guanine nucleotide exchange factor).
Genome Resources: Alliance (1),  Gene:569090 (1),  Ensembl(GRCz11):ENSDARG00000076179 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a306 Complex Unknown Unknown CRISPR
sa8969 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15674 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22714 Point Mutation Unknown Premature Stop ENU
    sa42610 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPr1-ngef 1
    CRISPR2-ngef 1
    CRISPR3-ngef 1
    CRISPR4-ngef 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ngef HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ngef VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process activation of GTPase activity (more)
    Molecular Function guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ngef-202 (1)    Ensembl 5097
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ngef No data available
    MARKER RELATIONSHIPS
    ngef Contained in: [BAC] CH211-278M11 (1), CH211-281L24 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005157788 (1)
    Genomic GenBank:CR759918 (1) 160374 nt
    Select Tool
    Polypeptide UniProtKB:E7FDB4 (1) 718 aa
    Sequence Information (all 9)
    ORTHOLOGY for ngef ( Chr: 15 )
    CITATIONS (16)