Gene

heatr5b

ID

ZDB-GENE-130530-676

Name

HEAT repeat containing 5B

Symbol

heatr5b Nomenclature History

Previous Names

zmp:0000000673 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to be involved in endocytosis; protein localization; and retrograde transport, endosome to Golgi. Predicted to be active in endocytic vesicle. Orthologous to human HEATR5B (HEAT repeat containing 5B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa8993	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa12245	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa15239	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With heatr5b Human Ortholog

No data available

Associated With heatr5b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR040108	Laa1/Sip1/HEATR5
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Repeat	IPR046837	Laa1/Sip1/HEATR5-like, HEAT repeat region

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Domain Details Per Protein

Protein	Additional Resources	Length	Armadillo-like helical	Armadillo-type fold	Laa1/Sip1/HEATR5	Laa1/Sip1/HEATR5-like, HEAT repeat region
UniProtKB:A0A0R4ISV1	InterPro	2025

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 13

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	heatr5b-201 (1) Ensembl	Ensembl		4,287 nt	Select Tool ZFIN BLAST
mRNA	heatr5b-202 (1) Ensembl	Ensembl		6,078 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-38O8	CU570800	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_009307044 (1)	8311 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU570800 (2)	60094 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0R4ISV1 (1)	2025 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

Species	Symbol	Chromosome	Accession #	Evidence
Human	HEATR5B	2	Ensembl:ENSG00000008869 Gene:54497 HGNC:29273 OMIM:619627	Amino acid sequence comparison (1)
Mouse	Heatr5b	17	Ensembl:ENSMUSG00000039414 Gene:320473 MGI:2444098	Amino acid sequence comparison (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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