Gene

jag2a

ID

ZDB-GENE-130530-549

Name

jagged canonical Notch ligand 2a

Symbol

jag2a Nomenclature History

Previous Names

zmp:0000000546 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have Notch binding activity and calcium ion binding activity. Predicted to be involved in Notch signaling pathway and multicellular organism development. Predicted to localize to integral component of membrane. Is expressed in ectoderm; pronephros; and yolk syncytial layer. Orthologous to human JAG2 (jagged canonical Notch ligand 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With jag2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Muscular dystrophy, limb-girdle, autosomal recessive 27	619566

Associated With jag2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001007	VWFC domain
Domain	IPR001774	Delta/Serrate/lag-2 (DSL) protein
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR011651	Notch ligand, N-terminal domain
Family	IPR026219	Jagged/Serrate protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	Delta/Serrate/lag-2 (DSL) protein	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like, conserved site	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Growth factor receptor cysteine-rich domain superfamily	Jagged/Serrate protein	Notch ligand, N-terminal domain	VWFC domain
UniProtKB:F1QVB9 InterPro	1136
UniProtKB:A0A8N7TDN4 InterPro	1230
UniProtKB:A0A8M2B354 InterPro	1192

Transcripts

Genome Browsers: No data available

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations