Gene

hecw1a

ID

ZDB-GENE-130530-1008

Name

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1a

Symbol

hecw1a Nomenclature History

Previous Names

zmp:0000001005 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

None

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa15027	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With hecw1a Human Ortholog

No data available

Associated With hecw1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR000569	HECT domain
Domain	IPR001202	WW domain
Domain	IPR032348	E3 ubiquitin-protein ligase HECW1/2, N-terminal
Domain	IPR037795	E3 ubiquitin-protein ligase HECW, C2 domain
Domain	IPR040524	E3 ubiquitin-protein ligase HECW1, helical box domain
Family	IPR050409	E3 ubiquitin-protein ligase
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR036020	WW domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	C2 domain	C2 domain superfamily	E3 ubiquitin-protein ligase	E3 ubiquitin-protein ligase HECW1/2, N-terminal	E3 ubiquitin-protein ligase HECW1, helical box domain	E3 ubiquitin-protein ligase HECW, C2 domain	HECT domain	HECT, E3 ligase catalytic domain	WW domain	WW domain superfamily
UniProtKB:A0A8M9PM33	InterPro	1561

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 24

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hecw1-201 (1) Ensembl	Ensembl	4,709 nt	Select Tool ZFIN BLAST
mRNA	hecw1-202 (1) Ensembl	Ensembl	4,657 nt	Select Tool ZFIN BLAST
mRNA	hecw1-203 (1) Ensembl	Ensembl	4,317 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-188F17	CR376794	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_021470254 (1)	9741 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR376794 (2)	139388 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M9PM33 (1)	1561 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	HECW1	7	Ensembl:ENSG00000002746 Gene:23072 HGNC:22195 OMIM:610384	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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