ZFIN ID: ZDB-GENE-130515-2
Gene Name: glypican 6b
Gene Symbol: gpc6b    Nomenclature History

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Previous Name: gpc6 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to be involved in several processes, including regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of presynapse assembly; and synaptic membrane adhesion. Predicted to localize to cell surface; extracellular region; and synapse. Is expressed in blastomere; central nervous system; intestine; and liver. Human ortholog(s) of this gene implicated in Keipert syndrome and omodysplasia. Orthologous to several human genes including GPC6 (glypican 6).
Genome Resources: Alliance (1),  Gene:100331176 (1),  Ensembl(GRCz11):ENSDARG00000104219 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa8472 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gpc6b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    omodysplasia Alliance Omodysplasia 1 258315
    DISEASE ASSOCIATED WITH gpc6b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of signal transduction (more)
    Cellular Component anchored component of membrane (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gpc6b No data available
    MARKER RELATIONSHIPS
    gpc6b Contained in: [Fosmid] CH1073-495O7
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001287541 (1) 1632 nt
    Genomic GenBank:FQ073925 (1) 2312011 nt Blast at MegaBLAST
    Polypeptide UniProtKB:V5NF92 (1) 543 aa
    Sequence Information (all 12)
    ORTHOLOGY for gpc6b ( Chr: 9 )
    CITATIONS (15)