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ZIRC
ZFIN ID: ZDB-GENE-130409-1
Gene Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Gene Symbol: pik3ca    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have 1-phosphatidylinositol-3-kinase activity; ATP binding activity; and phosphatidylinositol bisphosphate kinase activity. Involved in regulation of collateral sprouting in absence of injury. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome; breast cancer (multiple); carcinoma (multiple); and epidermal nevus. Is expressed in eye. Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha).
Genome Resources: Alliance (1),  Gene:561737 (1),  Ensembl(GRCz11):ENSDARG00000075456 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16936 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25449 Point Mutation Unknown Splice Site ENU
    sa35126 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35127 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35128 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45434 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pik3ca
    1
    CRISPR2-pik3ca
    1
    CRISPR3-pik3ca
    1
    MO1-pik3ca N/A 1
    MO2-pik3ca N/A 2
    PHENOTYPE
    Data: Fig. 6 from Schmidt et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH pik3ca HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    breast cancer Alliance Breast cancer, somatic 114480
    CLOVES syndrome Alliance CLOVE syndrome, somatic 612918
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    epidermal nevus Alliance Nevus, epidermal, somatic 162900
    hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
    lung cancer Alliance Nonsmall cell lung cancer, somatic 211980
    ovarian cancer Alliance Ovarian cancer, somatic 167000
    seborrheic keratosis Alliance Keratosis, seborrheic, somatic 182000
    stomach cancer Alliance Gastric cancer, somatic 613659
    CLAPO syndrome, somatic 613089
    Cowden syndrome 5 615108
    Macrodactyly, somatic 155500
    Megalencephaly-capillary malformation-polymicrogyria syndrome, somatic 602501
    DISEASE ASSOCIATED WITH pik3ca VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of collateral sprouting in absence of injury (more)
    Cellular Component cytoplasm (more)
    Molecular Function 1-phosphatidylinositol-3-kinase activity (more)
    GO Terms (all 21)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pik3ca-202 (1)    Ensembl 4279
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pik3ca No data available
    MARKER RELATIONSHIPS
    pik3ca Contained in: [BAC] DKEY-25G11 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009306176 (1)
    Genomic GenBank:BX548160 (1) 237930 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QAD7 (1) 1069 aa
    Sequence Clusters UniGene:117016 (1)
    Sequence Information (all 16)
    ORTHOLOGY for pik3ca ( Chr: 11 )
    CITATIONS (25)