Gene

tpp2

ID

ZDB-GENE-121214-290

Name

tripeptidyl peptidase 2

Symbol

tpp2 Nomenclature History

Previous Names

si:ch73-244f7.4

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable tripeptidyl-peptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be active in cytosol. Is expressed in embryonic structure. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Yang et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tpp2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Immunodeficiency 78 with autoimmunity and developmental delay	619220

Associated With tpp2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR022398	Peptidase S8, subtilisin, His-active site
Active_site	IPR023828	Peptidase S8, subtilisin, Ser-active site
Domain	IPR000209	Peptidase S8/S53 domain
Domain	IPR034051	Tripeptidyl-peptidase II domain
Family	IPR015500	Peptidase S8, subtilisin-related
Homologous_superfamily	IPR036852	Peptidase S8/S53 domain superfamily
Homologous_superfamily	IPR046939	Tripeptidyl-peptidase 2, C-terminal domain superfamily
Homologous_superfamily	IPR046940	Tripeptidyl peptidase II, Ig-like domain superfamily

Domain Details Per Protein

Protein	Length	Peptidase S8/S53 domain	Peptidase S8/S53 domain superfamily	Peptidase S8, subtilisin, His-active site	Peptidase S8, subtilisin-related	Peptidase S8, subtilisin, Ser-active site	Tripeptidyl-peptidase 2, C-terminal domain superfamily	Tripeptidyl-peptidase II domain	Tripeptidyl peptidase II, Ig-like domain superfamily
UniProtKB:A0A8M2BG24 InterPro	1262
UniProtKB:R4GDQ0 InterPro	1263
UniProtKB:A0A8M1RJV2 InterPro	1249

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	tpp2-201 (1) Ensembl	5496 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations