Gene

mast1a

ID
ZDB-GENE-121214-221
Name
microtubule associated serine/threonine kinase 1a
Symbol
mast1a Nomenclature History
Previous Names
  • si:ch211-212h16.3
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization; intracellular signal transduction; and peptidyl-serine phosphorylation. Human ortholog(s) of this gene implicated in mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to human MAST1 (microtubule associated serine/threonine kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mast1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations Alliance Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations 618273
Associated With mast1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR001478 PDZ domain
Domain IPR015022 Microtubule-associated serine/threonine-protein kinase, pre-PK domain
Domain IPR037711 Microtubule-associated serine/threonine-protein kinase, catalytic domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal Microtubule-associated serine/threonine-protein kinase, catalytic domain Microtubule-associated serine/threonine-protein kinase, pre-PK domain Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily PDZ domain PDZ superfamily Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:A0A8M3AKH8 1738
UniProtKB:E7F0L8 1717
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations