ZFIN ID: ZDB-GENE-121113-1
Gene Name: pregnancy-associated plasma protein A, pappalysin 1a
Gene Symbol: pappaa    Nomenclature History

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Previous Names: papp-a' (1), unfiltered (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Involved in several processes, including habituation; insulin-like growth factor receptor signaling pathway; and visual behavior. Is expressed in Mauthner neurons; anterior lateral line ganglion; hindbrain interneuron; posterior lateral line ganglion; and statoacoustic (VIII) ganglion. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PAPPA (pappalysin 1).
Genome Resources: Alliance (1),  Gene:101448000 (1),  Ensembl(GRCz11):ENSDARG00000101090 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
p170 Point Mutation Exon 3 Premature Stop ENU
sa17783 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17987 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33777 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33778 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pappaa N/A 1
    MO2-pappaa N/A 1
    MO3-pappaa N/A 1
    DISEASE ASSOCIATED WITH pappaa HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pappaa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process habituation (more)
    Molecular Function metalloendopeptidase activity (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pappaa No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001278805 (1) 5575 nt
    Genomic GenBank:CABZ01075582 (1) 15808 nt
    Polypeptide UniProtKB:M1XYM1 (1) 1629 aa
    Sequence Information (all 33)
    ORTHOLOGY for pappaa ( Chr: 5 )
    CITATIONS (22)