ZFIN ID: ZDB-GENE-121001-5
Gene Name: beta-1,4-glucuronyltransferase 1
Gene Symbol: b4gat1    Nomenclature History

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Previous Name: b3gnt1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have glucuronosyltransferase activity. Involved in muscle fiber development and protein glycosylation. Predicted to localize to Golgi apparatus. Used to study Walker-Warburg syndrome. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A13. Orthologous to human B4GAT1 (beta-1,4-glucuronyltransferase 1).
Genome Resources: Alliance (1),  Gene:101669768 (1),  Ensembl(GRCz11):ENSDARG00000077583 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34005 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-b4gat1 N/A 1
    DISEASE ASSOCIATED WITH b4gat1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital muscular dystrophy-dystroglycanopathy type A13 Alliance Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 13 615287
    DISEASE ASSOCIATED WITH b4gat1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Walker-Warburg syndrome WT + MO1-b4gat1 standard conditions Buysse et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process muscle fiber development (more)
    Cellular Component Golgi apparatus (more)
    Molecular Function glucuronosyltransferase activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA b4gat1-201 (1)    Ensembl 5080
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM b4gat1 No data available
    MARKER RELATIONSHIPS
    b4gat1 Contained in: [BAC] CH211-42C5
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001278828 (1) 1643 nt
    Genomic GenBank:BX324230 (1) 179902 nt
    Select Tool
    Polypeptide UniProtKB:L7YAI7 (1) 431 aa
    Sequence Information (all 9)
    ORTHOLOGY for b4gat1 ( Chr: 7 )
    CITATIONS (18)