ZFIN ID: ZDB-GENE-120919-4
Gene Name: itchy E3 ubiquitin protein ligase a
Gene Symbol: itcha    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have ubiquitin protein ligase activity. Predicted to be involved in positive regulation of protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to localize to cytoplasm. Is expressed in posterior lateral line primordium. Orthologous to human ITCH (itchy E3 ubiquitin protein ligase).
Genome Resources: Alliance (1),  Gene:100331274 (1),  Ensembl(GRCz11):ENSDARG00000074903 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20834 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26849 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-itcha N/A 1
    MO2-itcha N/A 1
    PHENOTYPE
    Data: Fig. 3 from Angers et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH itcha HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Autoimmune disease, multisystem, with facial dysmorphism 613385
    DISEASE ASSOCIATED WITH itcha VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ubiquitin-dependent protein catabolic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function transferase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itcha-202 (1)    Ensembl 3374
    ncRNA itcha-002 (1) 585
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itcha No data available
    MARKER RELATIONSHIPS
    itcha Contained in: [BAC] CH211-60J9 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001287095 (1) 2792 nt
    Genomic GenBank:CU929339 (1) 181638 nt
    Select Tool
    Polypeptide UniProtKB:U6C7X6 (1) 851 aa
    Sequence Information (all 11)
    ORTHOLOGY for itcha ( Chr: 6 )
    CITATIONS (18)