Gene

itcha

ID
ZDB-GENE-120919-4
Name
itchy E3 ubiquitin protein ligase a
Symbol
itcha Nomenclature History
Previous Names
  • itch
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have ubiquitin protein ligase activity. Predicted to be involved in positive regulation of protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to localize to cytoplasm. Is expressed in posterior lateral line primordium. Orthologous to human ITCH (itchy E3 ubiquitin protein ligase).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Angers et al., 2014
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Angers et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With itcha Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Autoimmune disease, multisystem, with facial dysmorphism 613385
Associated With itcha Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000008 C2 domain
Domain IPR000569 HECT domain
Domain IPR001202 WW domain
Family IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR035983 HECT, E3 ligase catalytic domain
Homologous_superfamily IPR036020 WW domain superfamily
Domain Details Per Protein
Protein Length C2 domain C2 domain superfamily E3 ubiquitin-protein ligase, SMURF1 type HECT domain HECT, E3 ligase catalytic domain WW domain WW domain superfamily
UniProtKB:U6C7X6 851
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations