Gene
tnfrsf11a
- ID
- ZDB-GENE-120910-2
- Name
- tumor necrosis factor receptor superfamily, member 11a, NFKB activator
- Symbol
- tnfrsf11a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Paget's disease of bone; autosomal recessive osteopetrosis 7; bone development disease; familial expansile osteolysis; and osteoporosis. Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive osteopetrosis 7 | Alliance | Osteopetrosis, autosomal recessive 7 | 612301 |
| familial expansile osteolysis | Alliance | Osteolysis, familial expansile | 174810 |
| Paget's disease of bone 2 | Alliance | {Paget disease of bone 2, early-onset} | 602080 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor superfamily member 11A |
|---|---|---|---|
|
UniProtKB:A0A8M9PE80
|
497 | ||
|
UniProtKB:A0A8M3AVZ3
|
497 | ||
|
UniProtKB:E7F027
|
574 | ||
|
UniProtKB:A0A8M9P635
|
506 | ||
|
UniProtKB:A0A8M9Q403
|
506 | ||
|
UniProtKB:A0A8M9PQZ0
|
236 | ||
|
UniProtKB:A0A8M9Q849
|
574 | ||
|
UniProtKB:A0A8M3ANI1
|
236 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfrsf11a-201
(1)
|
Ensembl | 3,624 nt |
Interactions and Pathways
No data available
Plasmids
No data available