ZFIN ID: ZDB-GENE-120814-1
Gene Name: Rho guanine nucleotide exchange factor (GEF) 10-like a
Gene Symbol: arhgef10la    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have Rho guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Human ortholog(s) of this gene implicated in ovarian endometrial cancer and ovarian serous carcinoma. Orthologous to human ARHGEF10L (Rho guanine nucleotide exchange factor 10 like).
Genome Resources: Alliance (1),  Gene:799435 (1),  Ensembl(GRCz11):ENSDARG00000088630 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21933 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30949 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31838 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31839 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35105 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38849 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44742 Point Mutation Unknown Unknown ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH arhgef10la HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH arhgef10la VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process actin cytoskeleton organization (more)
    Molecular Function guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000219 Dbl homology (DH) domain
    Family IPR039919 Rho guanine nucleotide exchange factor 10/17
    Homologous_superfamily IPR011993 PH-like domain superfamily
    Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
    Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arhgef10la-202 (1)    Ensembl 8423
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arhgef10la No data available
    MARKER RELATIONSHIPS
    arhgef10la Contained in: [BAC] CH211-9N7 (1), CH211-199M8 (1), DKEY-66P15 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009306101 (1)
    Genomic GenBank:BX548000 (1) 216767 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4ITX4 (1) 1314 aa
    Sequence Information (all 18)
    ORTHOLOGY for arhgef10la ( Chr: 11 )
    CITATIONS (12)