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ZIRC
ZFIN ID: ZDB-GENE-120614-1
Gene Name: O-6-methylguanine-DNA methyltransferase
Gene Symbol: mgmt    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have methylated-DNA-[protein]-cysteine S-methyltransferase activity. Predicted to be involved in DNA repair. Predicted to localize to the nucleoplasm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); malignant glioma (multiple); retinoblastoma; and urinary bladder cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase).
Genome Resources: Alliance (1),  Gene:553368 (1),  Ensembl(GRCz11):ENSDARG00000043275 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mgmt HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH mgmt VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process DNA repair (more)
Cellular Component nucleus (more)
Molecular Function catalytic activity (more)
GO Terms (all 4)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mgmt-201 (1)    Ensembl 1061
mgmt-202 (1)    Ensembl 773
mgmt-203 (1)    Ensembl 911
mgmt-204 (1)    Ensembl 749
mgmt-205 (1)    Ensembl 800
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mgmt No data available
MARKER RELATIONSHIPS
mgmt Contained in: [BAC] CH211-207N2 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001256243 (1) 1093 bp
Genomic GenBank:BX005375 (1) 214178 bp Blast at MegaBLAST
Polypeptide UniProtKB:Q568B0 (1) 214 aa
Sequence Clusters UniGene:81911 (1)
Sequence Information (all 16)
ORTHOLOGY for mgmt ( Chr: 17 )
CITATIONS (12)