Gene

mgmt

ID
ZDB-GENE-120614-1
Name
O-6-methylguanine-DNA methyltransferase
Symbol
mgmt Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable methylated-DNA-[protein]-cysteine S-methyltransferase activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within cellular response to DNA damage stimulus and methylation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mgmt Human Ortholog
No data available
Associated With mgmt Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site
Domain IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain
Domain IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
Homologous_superfamily IPR036217 Methylated DNA-protein cysteine methyltransferase, DNA binding domain
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036631 Methylated DNA-protein cysteine methyltransferase domain superfamily
Domain Details Per Protein
Protein Length Methylated DNA-protein cysteine methyltransferase, DNA binding domain Methylated DNA-protein cysteine methyltransferase domain superfamily Methylated-DNA-[protein]-cysteine S-methyltransferase, active site Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding Methylguanine DNA methyltransferase, ribonuclease-like domain Winged helix-like DNA-binding domain superfamily
UniProtKB:X1WB89 187
UniProtKB:F1R3V2 192
UniProtKB:Q568B0 214
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations