ZFIN ID: ZDB-GENE-120529-1
Gene Name: ring finger and WD repeat domain 3
Gene Symbol: rfwd3    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity and ubiquitin-protein transferase activity. Predicted to be involved in interstrand cross-link repair and protein ubiquitination. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Fanconi anemia. Orthologous to human RFWD3 (ring finger and WD repeat domain 3).
Genome Resources: Alliance (1),  Gene:100329327 (1),  Ensembl(GRCz11):ENSDARG00000087752 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31117 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39496 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rfwd3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Fanconi anemia, complementation group W 617784
    DISEASE ASSOCIATED WITH rfwd3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process interstrand cross-link repair (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rfwd3-202 (1)    Ensembl 655
    rfwd3-203 (1)    Ensembl 2268
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rfwd3 No data available
    MARKER RELATIONSHIPS
    rfwd3 Contained in: [BAC] DKEY-234I14 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002666962 (1)
    Genomic GenBank:CU207301 (1) 174391 nt
    Select Tool
    Polypeptide UniProtKB:X1WE22 (1) 632 aa
    Sequence Information (all 8)
    ORTHOLOGY for rfwd3 ( Chr: 25 )
    CITATIONS (13)