Gene

il6

ID
ZDB-GENE-120509-1
Name
interleukin 6 (interferon, beta 2)
Symbol
il6 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have cytokine activity and interleukin-6 receptor binding activity. Involved in hematopoietic stem cell differentiation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Is expressed in several structures, including epidermis; immune system; lateral line; liver; and peripheral olfactory organ. Orthologous to human IL6 (interleukin 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
57 figures from 45 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
arteriovenous malformations of the brain Alliance {Intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to} 108010
inflammatory bowel disease 1 Alliance {Crohn disease-associated growth failure} 266600
juvenile rheumatoid arthritis Alliance {Rheumatoid arthritis, systemic juvenile} 604302
type 1 diabetes mellitus Alliance {Type 1 diabetes mellitus} 222100
type 2 diabetes mellitus Alliance {Type 2 diabetes mellitus} 125853
{Kaposi sarcoma, susceptibility to} 148000
Associated With il6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR003574 Interleukin-6
Family IPR030474 Interleukin-6/GCSF/MGF
Homologous_superfamily IPR009079 Four-helical cytokine-like, core
Domain Details Per Protein
Protein Length Four-helical cytokine-like, core Interleukin-6 Interleukin-6/GCSF/MGF
UniProtKB:H9A0J9 231
Transcripts
Genome Browsers
No data available
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations