ZFIN ID: ZDB-GENE-120312-1
Gene Name: ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
Gene Symbol: ube2d2    Nomenclature History

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Previous Names: zgc:55886, zgc:77149, zmp:0000000618 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in negative regulation of smoothened signaling pathway. Predicted to localize to nucleus and ubiquitin ligase complex. Orthologous to several human genes including UBE2D2 (ubiquitin conjugating enzyme E2 D2).
Genome Resources: Alliance (1),  Gene:393934 (1),  Ensembl(GRCz11):ENSDARG00000043484 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55886]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1274 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15846 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ube2d2 N/A 1
    MO2-ube2d2 N/A 1
    DISEASE ASSOCIATED WITH ube2d2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ube2d2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of smoothened signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function ATP binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ube2d2-202 (1)    Ensembl 1246
    ube2d2-203 (1)    Ensembl 450
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ube2d2 No data available
    MARKER RELATIONSHIPS
    ube2d2 Contained in: [BAC] CH73-345I5
    [Fosmid] CH1073-253L17
    ube2d2 Encodes: [cDNA] MGC:55886 (1), MGC:77149 (1), MGC:192124 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200959 (1) 1935 nt
    Genomic GenBank:CU570692 (1) 88680 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZUK1 (1) 147 aa
    Sequence Information (all 20)
    ORTHOLOGY for ube2d2 ( Chr: 14 )
    CITATIONS (28)