Gene
irs4a
- ID
- ZDB-GENE-120215-92
- Name
- insulin receptor substrate 4a
- Symbol
- irs4a Nomenclature History
- Previous Names
-
- si:ch73-362m14.1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to localize to cytosol and plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism. Orthologous to human IRS4 (insulin receptor substrate 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zhang et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nongoitrous hypothyroidism 9 | Alliance | Hypothyroidism, congenital, nongoitrous, 9 | 301035 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Insulin receptor substrate | IRS-type PTB domain | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|
|
UniProtKB:E7FCJ4
|
1051 |
Interactions and Pathways
No data available
Plasmids
No data available