Gene
htr2ab
- ID
- ZDB-GENE-120215-60
- Name
- 5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b
- Symbol
- htr2ab Nomenclature History
- Previous Names
-
- si:dkey-276l13.4
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have G protein-coupled serotonin receptor activity. Involved in commissural neuron axon guidance. Predicted to localize to dendrite and integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Xing et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alcohol dependence | Alliance | {Alcohol dependence, susceptibility to} | 103780 |
| melancholic depression | Alliance | {Major depressive disorder, response to citalopram therapy in} | 608516 |
| melancholic depression | Alliance | {Seasonal affective disorder, susceptibility to} | 608516 |
| schizophrenia | Alliance | {Schizophrenia, susceptibility to} | 181500 |
| {Anorexia nervosa, susceptibility to} | 606788 | ||
| {Obsessive-compulsive disorder, susceptibility to} | 164230 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | 5-Hydroxytryptamine 2A receptor | 5-hydroxytryptamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B093
|
458 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
htr2ab-201
(1)
|
Havana | 1552 nt |
Interactions and Pathways
No data available
Plasmids
No data available