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Gene

slc16a2

ID
ZDB-GENE-120117-1
Name
solute carrier family 16 member 2
Symbol
slc16a2 Nomenclature History
Previous Names
  • MCT8 (1)
Type
protein_coding_gene
Location
Unmapped
Description
Enables thyroid hormone binding activity and thyroid hormone transmembrane transporter activity. Acts upstream of or within several processes, including chordate embryonic development; nervous system development; and thyroid gland development. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; digestive system; eye; and hindbrain neural keel. Used to study Allan-Herndon-Dudley syndrome. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome and intellectual disability. Orthologous to human SLC16A2 (solute carrier family 16 member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc16a2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Allan-Herndon-Dudley syndrome Alliance Allan-Herndon-Dudley syndrome 300523
Associated With slc16a2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020846 Major facilitator superfamily domain
Family IPR011701 Major facilitator superfamily
Family IPR030761 Monocarboxylate transporter 8
Homologous_superfamily IPR036259 MFS transporter superfamily
Domain Details Per Protein
Protein Length Major facilitator superfamily Major facilitator superfamily domain MFS transporter superfamily Monocarboxylate transporter 8
UniProtKB:G8XYX6 526
UniProtKB:L7T0T8 526
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations