ogdhl

ID

ZDB-GENE-111201-4

Name

oxoglutarate dehydrogenase L

Symbol

ogdhl Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome. Orthologous to human OGDHL (oxoglutarate dehydrogenase L).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ogdhl Human Ortholog

No data available

Associated With ogdhl Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001017	Dehydrogenase, E1 component
Domain	IPR005475	Transketolase-like, pyrimidine-binding domain
Domain	IPR031717	2-oxoglutarate dehydrogenase E1 component/KDG, C-terminal
Domain	IPR032106	2-oxoglutarate dehydrogenase E1 component, N-terminal domain
Family	IPR011603	2-oxoglutarate dehydrogenase E1 component
Homologous_superfamily	IPR029061	Thiamin diphosphate-binding fold
Homologous_superfamily	IPR042179	Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily