Gene

mars2

ID
ZDB-GENE-111201-1
Name
methionyl-tRNA synthetase 2, mitochondrial
Symbol
mars2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable ATP binding activity and methionine-tRNA ligase activity. Predicted to act upstream of or within methionyl-tRNA aminoacylation. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mars2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined oxidative phosphorylation deficiency 25 Alliance ?Combined oxidative phosphorylation deficiency 25 616430
spastic ataxia 3 Alliance Spastic ataxia 3, autosomal recessive 611390
Associated With mars2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR015413 Methionyl/Leucyl tRNA synthetase
Domain IPR033911 Methioninyl-tRNA synthetase core domain
Domain IPR041872 Methionyl-tRNA synthetase, anticodon-binding domain
Family IPR014758 Methionyl-tRNA synthetase
Homologous_superfamily IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ia, anticodon-binding Methioninyl-tRNA synthetase core domain Methionyl/Leucyl tRNA synthetase Methionyl-tRNA synthetase Methionyl-tRNA synthetase, anticodon-binding domain Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:E7F5M3 595
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations