Gene

lgr4

ID
ZDB-GENE-111013-1
Name
leucine-rich repeat containing G protein-coupled receptor 4
Symbol
lgr4 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable transmembrane signaling receptor activity. Involved in hypothalamus gonadotrophin-releasing hormone neuron development. Predicted to be located in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; central nervous system; digestive system; head; and pectoral fin bud. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Mancini et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lgr4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Delayed puberty, self-limited 619613
{Bone mineral density, low, susceptibility to} 615311
Associated With lgr4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR002131 Glycoprotein hormone receptor family
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Domain Details Per Protein
Protein Length Glycoprotein hormone receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype
UniProtKB:E7FE13 971
UniProtKB:A0A2R8RP16 947
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations