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ZIRC
ZFIN ID: ZDB-GENE-111005-2
Gene Name: cytochrome P450, family 27, subfamily B, polypeptide 1
Gene Symbol: cyp27b1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Exhibits calcidiol 1-monooxygenase activity. Involved in hematopoietic stem cell proliferation. Human ortholog(s) of this gene implicated in obesity; rickets; and type 1 diabetes mellitus. Is expressed in heart; kidney; liver; and spleen. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1).
Genome Resources: Alliance (1),  Gene:793309 (1),  Ensembl(GRCz11):ENSDARG00000045015 (2)
Note: Based on ENSDART00000066178 in ZDB-PUB-110907-25.
GENE EXPRESSION
All Expression Data: 7 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34997 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cyp27b1 N/A 2
    DISEASE ASSOCIATED WITH cyp27b1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    rickets Alliance Vitamin D-dependent rickets, type I 264700
    DISEASE ASSOCIATED WITH cyp27b1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hematopoietic stem cell proliferation (more)
    Molecular Function calcidiol 1-monooxygenase activity (more)
    GO Terms (all 9)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp27b1-201 (1)    Ensembl 2142
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp27b1 No data available
    MARKER RELATIONSHIPS
    cyp27b1 Contained in: [BAC] CH211-90A2 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001311791 (1)
    Genomic GenBank:CU929297 (1) 37104 bp
    Select Tool
    Polypeptide UniProtKB:A0A140LGN8 (1) 506 aa
    Sequence Information (all 9)
    ORTHOLOGY for cyp27b1 ( Chr: 11 )
    CITATIONS (16)