ZFIN ID: ZDB-GENE-110726-1
Gene Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Gene Symbol: svep1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in epidermal cell differentiation and lymph vessel development. Is expressed in fin bud; pharyngeal arch 3-7; and trunk. Orthologous to human SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1).
Genome Resources: Alliance (1),  Gene:567357 (1),  Ensembl(GRCz11):ENSDARG00000013526 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu4767 Point Mutation Exon 14 Premature Stop ENU
hu6123 Point Mutation Exon 4 Premature Stop ENU
hu6985 Point Mutation Exon 35 Premature Stop ENU
ncv106 Small Deletion Unknown Unknown TALEN
sa1285 Point Mutation Unknown Splice Site ENU
sa9584 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12993 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17476 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20926 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31569 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31570 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34058 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34059 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34060 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40882 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44658 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-svep1 N/A 1
    MO2-svep1 N/A 1
    TALEN1-svep1 1
    DISEASE ASSOCIATED WITH svep1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH svep1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process epidermal cell differentiation (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000436 Sushi/SCR/CCP domain
    Domain IPR000742 EGF-like domain
    Family IPR001759 Pentraxin-related
    Domain IPR001881 EGF-like calcium-binding domain
    Domain IPR002035 von Willebrand factor, type A
    Domain IPR003410 HYR domain
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    Conserved_site IPR013032 EGF-like, conserved site
    Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    Domain IPR024731 EGF domain
    Homologous_superfamily IPR035976 Sushi/SCR/CCP superfamily
    Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA svep1-201 (1)    Ensembl 11731
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM svep1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(svep1:GAL4FF) svep1 GAL4FF Danio rerio 1 1
    TgBAC(svep1:mCherry) svep1 mCherry Danio rerio 1 1
    MARKER RELATIONSHIPS
    svep1 Contained in: [BAC] CH211-216P19, DKEY-11K2 (1) (order this), DKEY-97O7 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_690650 (1) 11644 bp
    Genomic GenBank:CR318603 (1) 188703 bp
    Select Tool
    Polypeptide UniProtKB:A0A1D5NSM8 (1) 3615 aa
    Sequence Information (all 21)
    ORTHOLOGY for svep1 ( Chr: 7 )
    CITATIONS (16)