ZFIN ID: ZDB-GENE-110713-1
Gene Name: heat shock cognate 70-kd protein, tandem duplicate 3
Gene Symbol: hsp70.3    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have several functions, including ATP binding activity; misfolded protein binding activity; and protein folding chaperone. Involved in camera-type eye morphogenesis. Predicted to colocalize with COP9 signalosome. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1B (heat shock protein family A (Hsp70) member 1B).
Genome Resources: Alliance (1),  Gene:30671 (1),  Ensembl(GRCz11):ENSDARG00000021924 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-hsp70.3
1
CRISPR2-hsp70.3
1
MO1-hsp70.3 N/A 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hsp70.3 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH hsp70.3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process camera-type eye morphogenesis (more)
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 19)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA hsp70.3-201 (1)    Ensembl 2358
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hsp70.3
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(krt4:hsp70.3,mCherry) krt4 hsp70.3mCherry Danio rerio 1 2
Tg(lyz:hsp70.3,EGFP) lyz EGFPhsp70.3 Danio rerio 1 2
MARKER RELATIONSHIPS
hsp70.3 Contained in: [BAC] CH73-46H18
hsp70.3 Encodes: [cDNA] MGC:65778 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131397 (1) 2770 nt
Genomic GenBank:FP016243 (1) 129600 nt
Select Tool
Polypeptide UniProtKB:Q9IAC1 (1) 658 aa
Sequence Information (all 13)
ORTHOLOGY for hsp70.3 ( Chr: 3 )
CITATIONS (42)