ZFIN ID: ZDB-GENE-110606-6
Gene Name: argonaute RISC catalytic component 2
Gene Symbol: ago2    Nomenclature History

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Previous Names: Ago2 (1), eif2c2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Exhibits miRNA binding activity and pre-miRNA binding activity. Involved in nucleate erythrocyte differentiation and pre-miRNA processing. Predicted to localize to P-body; RISC complex; and mRNA cap binding activity complex. Is expressed in several structures, including eye; fin; integument; intermediate cell mass of mesoderm; and pleuroperitoneal region. Orthologous to human AGO2 (argonaute RISC catalytic component 2).
Genome Resources: Alliance (1),  Gene:570630 (1),  Ensembl(GRCz11):ENSDARG00000061268 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa196 Point Mutation Unknown Premature Stop ENU
sa23583 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23584 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ya100 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
    DISEASE ASSOCIATED WITH ago2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ago2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pre-miRNA processing (more)
    Cellular Component cytoplasm (more)
    Molecular Function miRNA binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ago2-201 (1)    Ensembl 2966
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ago2 No data available
    MARKER RELATIONSHIPS
    ago2 Contained in: [BAC] CH73-351F10, CH211-57N23
    ago2 Encodes: [EST] wz1283
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001302222 (1)
    Genomic GenBank:CU896645 (1) 162129 nt
    Select Tool
    Polypeptide UniProtKB:E7EXY4 (1) 873 aa
    Sequence Information (all 14)
    ORTHOLOGY for ago2 ( Chr: 19 )
    CITATIONS (32)