ZFIN ID: ZDB-GENE-110524-4
Gene Name: thyroid stimulating hormone receptor
Gene Symbol: tshr    Nomenclature History

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Previous Names: manet (1), opallus (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits thyroid-stimulating hormone receptor activity. Involved in skeletal system development. Predicted to localize to integral component of plasma membrane. Is expressed in thyroid follicle and thyroid primordium. Used to study hyperthyroidism. Human ortholog(s) of this gene implicated in Graves' disease; cardiomyopathy; congenital nongoitrous hypothyroidism 1; and mitral valve prolapse. Orthologous to human TSHR (thyroid stimulating hormone receptor).
Genome Resources: Alliance (1),  Gene:560609 (1),  Ensembl(GRCz11):ENSDARG00000037195 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:High-pec (42.0h-48.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1071 Point Mutation Unknown Missense ENU
sa5947 Point Mutation Unknown Splice Site ENU
sa12444 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36962 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • wpr23e1 Complex Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tshr
    1
    CRISPR2-tshr
    1
    MO1-tshr N/A 1
    DISEASE ASSOCIATED WITH tshr HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital nongoitrous hypothyroidism 1 Alliance Hypothyroidism, congenital, nongoitrous, 1 275200
    hyperthyroidism Alliance Hyperthyroidism, familial gestational 603373
    Hyperthyroidism, nonautoimmune 609152
    Thyroid adenoma, hyperfunctioning, somatic
    Thyroid carcinoma with thyrotoxicosis
    DISEASE ASSOCIATED WITH tshr VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    hyperthyroidism tshrb1071/b1071 standard conditions Hur et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process skeletal system development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function thyroid-stimulating hormone receptor activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tshr No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001145763 (1)
    Genomic GenBank:FQ377935 (1) 40542 nt
    Select Tool
    Polypeptide UniProtKB:C0SKM5 (1) 757 aa
    Sequence Information (all 11)
    ORTHOLOGY for tshr ( Chr: 20 )
    CITATIONS (41)