Gene

kif5ab

ID
ZDB-GENE-110510-3
Name
kinesin family member 5A, b
Symbol
kif5ab Nomenclature History
Previous Names
  • si:ch73-130n22.1
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex; axon guidance; and synaptic vesicle transport. Predicted to localize to kinesin complex and microtubule. Is expressed in nervous system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (kinesin family member 5A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from Campbell et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kif5ab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spastic paraplegia 10 Alliance Spastic paraplegia 10, autosomal dominant 604187
Myoclonus, intractable, neonatal 617235
{Amyotrophic lateral sclerosis, susceptibility to, 25} 617921
Associated With kif5ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019821 Kinesin motor domain, conserved site
Domain IPR001752 Kinesin motor domain
Family IPR027640 Kinesin-like protein
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length Kinesin-like protein Kinesin motor domain Kinesin motor domain, conserved site Kinesin motor domain superfamily P-loop containing nucleoside triphosphate hydrolase
UniProtKB:E7F8S2 992
UniProtKB:A0A2R8Q547 323
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations