Gene
kif5ab
- ID
- ZDB-GENE-110510-3
- Name
- kinesin family member 5A, b
- Symbol
- kif5ab Nomenclature History
- Previous Names
-
- si:ch73-130n22.1
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex; axon guidance; and synaptic vesicle transport. Predicted to localize to kinesin complex and microtubule. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Is expressed in nervous system. Orthologous to human KIF5A (kinesin family member 5A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Campbell et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 25 | Alliance | {Amyotrophic lateral sclerosis, susceptibility to, 25} | 617921 |
| hereditary spastic paraplegia 10 | Alliance | Spastic paraplegia 10, autosomal dominant | 604187 |
| Myoclonus, intractable, neonatal | 617235 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1PSD5
|
1023 | |||||
|
UniProtKB:A0A8M3ATT8
|
1050 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kif5ab-201
(1)
|
Ensembl | 3,262 nt | ||
| mRNA |
kif5ab-202
(1)
|
Ensembl | 972 nt |
Interactions and Pathways
No data available
Plasmids
No data available