Gene

grm8a

ID
ZDB-GENE-110421-2
Name
glutamate receptor, metabotropic 8a
Symbol
grm8a Nomenclature History
Previous Names
  • grm8b
  • mglur8a (1)
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable group III metabotropic glutamate receptor activity. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain and retinal neural layer. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Haug et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grm8a Human Ortholog
No data available
Associated With grm8a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017979 GPCR, family 3, conserved site
Domain IPR001828 Receptor, ligand binding region
Domain IPR011500 GPCR, family 3, nine cysteines domain
Domain IPR017978 GPCR family 3, C-terminal
Family IPR000162 GPCR, family 3, metabotropic glutamate receptor
Family IPR000337 GPCR, family 3
Family IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Homologous_superfamily IPR038550 GPCR, family 3, nine cysteines domain superfamily
Domain Details Per Protein
Protein Length GPCR, family 3 GPCR, family 3, conserved site GPCR family 3, C-terminal GPCR, family 3, metabotropic glutamate receptor GPCR, family 3, metabotropic glutamate receptor 4 GPCR, family 3, nine cysteines domain GPCR, family 3, nine cysteines domain superfamily Periplasmic binding protein-like I Receptor, ligand binding region
UniProtKB:E7FH00 909
UniProtKB:X1WG02 159
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations