Gene

frk

ID
ZDB-GENE-110411-7
Name
fyn-related Src family tyrosine kinase
Symbol
frk Nomenclature History
Previous Names
  • frk (2)
  • frka (1)
  • fynrk
  • sb:eu490
  • si:ch1073-112f1.1
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including innate immune response; peptidyl-tyrosine autophosphorylation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human FRK (fyn related Src family tyrosine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Xiong et al., 2022
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With frk Human Ortholog
No data available
Associated With frk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000980 SH2 domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001452 SH3 domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR050198 Non-receptor tyrosine kinases involved in cell signaling
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Non-receptor tyrosine kinases involved in cell signaling Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain
UniProtKB:A0A8M9PC12 512
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA frk-201 (1) Ensembl 1539 nt
mRNA frk-202 (1) Havana 1854 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations