Gene

hace1

ID
ZDB-GENE-110411-52
Name
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Symbol
hace1 Nomenclature History
Previous Names
  • si:ch73-97e20.2
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have Rab GTPase binding activity and ubiquitin-protein transferase activity. Involved in heart development and negative regulation of reactive oxygen species biosynthetic process. Predicted to localize to Golgi membrane. Is expressed in brain; heart; and pronephros. Orthologous to human HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Daugaard et al., 2013
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Razaghi et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hace1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Spastic paraplegia and psychomotor retardation with or without seizures 616756
Associated With hace1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000569 HECT domain
Domain IPR020683 Ankyrin repeat-containing domain
Homologous_superfamily IPR035983 HECT, E3 ligase catalytic domain
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily HECT domain HECT, E3 ligase catalytic domain
UniProtKB:F8W2M1 904
UniProtKB:K7DY07 905
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations