ZFIN ID: ZDB-GENE-110411-4
Gene Name: integrin, beta 2
Gene Symbol: itgb2    Nomenclature History

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Previous Name: si:dkey-260n18.4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have amyloid-beta binding activity and integrin binding activity. Involved in definitive hemopoiesis. Predicted to localize to cell surface; focal adhesion; and integrin complex. Is expressed in caudal hematopoietic tissue. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2).
Genome Resources: Alliance (1),  Gene:557797 (1),  Ensembl(GRCz11):ENSDARG00000016939 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ioz105 Small Deletion Unknown Unknown CRISPR
sa11250 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-itgb2 1
    MO1-itgb2 N/A 1
    DISEASE ASSOCIATED WITH itgb2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    leukocyte adhesion deficiency 1 Alliance Leukocyte adhesion deficiency 116920
    DISEASE ASSOCIATED WITH itgb2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process definitive hemopoiesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function signaling receptor activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itgb2-201 (1)    Ensembl 3489
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itgb2 No data available
    MARKER RELATIONSHIPS
    itgb2 Contained in: [BAC] CH211-229G14 (1), DKEY-260N18 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_680920 (1) 3707 nt
    Genomic GenBank:BX510317 (1) 159458 nt
    Select Tool
    Polypeptide UniProtKB:E7FCN5 (1) 768 aa
    Sequence Information (all 6)
    ORTHOLOGY for itgb2 ( Chr: 9 )
    CITATIONS (21)