Gene

thbd

ID
ZDB-GENE-110411-281
Name
thrombomodulin
Symbol
thbd Nomenclature History
Previous Names
  • si:ch1073-471m19.4
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and transmembrane signaling receptor activity. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With thbd Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thrombophilia due to thrombomodulin defect Alliance Thrombophilia due to thrombomodulin defect 614486
{Hemolytic uremic syndrome, atypical, susceptibility to, 6} 612926
Associated With thbd Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001304 C-type lectin-like
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR015149 Thrombomodulin-like, EGF-like
Domain IPR026823 Complement Clr-like EGF domain
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR016186 C-type lectin-like/link domain superfamily
Homologous_superfamily IPR016187 C-type lectin fold
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Complement Clr-like EGF domain C-type lectin fold C-type lectin-like C-type lectin-like/link domain superfamily EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Thrombomodulin-like, EGF-like
UniProtKB:F8W3I7 468
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations