ZFIN ID: ZDB-GENE-110411-108
Gene Name: integrin alpha 4
Gene Symbol: itga4    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: si:ch73-119a20.1

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to be involved in cell adhesion and integrin-mediated signaling pathway. Predicted to localize to integrin complex. Is expressed in mid cerebral vein and notochord. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic cancer. Orthologous to human ITGA4 (integrin subunit alpha 4).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000103056 (1)
GENE EXPRESSION
All Expression Data: Fig. S10 from K√§rpanen et al., 2017
Wild-type Stages, Structures: Pharyngula:Prim-15 (30.0h-36.0h) to Pharyngula:Prim-15 (30.0h-36.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cas005 Insertion Exon 13 Unknown ENU
cas010 Small Deletion Exon 1 Unknown CRISPR
ko108 Small Deletion Unknown Unknown CRISPR
sa14884 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34752 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34753 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-itga4 1
    CRISPR2-itga4 2
    CRISPR3-itga4 2
    MO1-itga4 N/A 1
    MO2-itga4 N/A 1
    DISEASE ASSOCIATED WITH itga4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH itga4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process NOT   lymphangiogenesis (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itga4-201 (1)    Ensembl 2270
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itga4 No data available
    MARKER RELATIONSHIPS
    itga4 Contained in: [BAC] CH73-119A20 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:FP102798 (1) 51947 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4ICS1 (1) 1018 aa
    Sequence Information (all 3)
    ORTHOLOGY for itga4 ( Chr: 9 )
    CITATIONS (18)